Systemic oxidant/antioxidant balance in human abdominal aortic aneurysm

Mentese U., TURAN İ., Usta S., DEMİR S., Koral O., Mentese S. O., ...Daha Fazla

PERFUSION-UK, cilt.31, sa.4, ss.288-294, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1177/0267659115598856
  • Dergi Adı: PERFUSION-UK
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.288-294
  • Anahtar Kelimeler: abdominal aortic aneurysm, oxidative stress, total oxidant status, total antioxidant status, cardiovascular, OXIDATIVE STRESS, GENE-EXPRESSION, MECHANISMS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p<0.001, p<0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r=0.592, p<0.001) and OSI values (r=0.598, p<0.001). A cut-off value of 17.68 mu mol H2O2 equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.