Neonatal Sepsis Caused by Gram-negative Bacteria in a Neonatal Intensive Care Unit: A Six Years Analysis

MUTLU M., ASLAN Y., SAYGIN B., YILMAZ G., BAYRAMOĞLU G., Koksal I.

HONG KONG JOURNAL OF PAEDIATRICS, cilt.16, sa.4, ss.253-257, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2011
  • Dergi Adı: HONG KONG JOURNAL OF PAEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.253-257
  • Anahtar Kelimeler: Antibiotic susceptibility, Gram-negative bacteria, Newborn, Nosocomial sepsis, NOSOCOMIAL INFECTIONS, ONSET
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: To analyse the Gram-negative bacteriological profile of nosocomial sepsis and antibiotic susceptibility patterns. Methods: Neonates clinically diagnosed with sepsis and whose blood cultures tested positive for Gram-negative microorganisms from 2002 to 2008, retrospectively. Results: 143 cases of neonatal sepsis caused by Gram-negative microorganisms were identified. Eighty-one percent (n=116) of these had nosocomial sepsis. In nosocomial sepsis, the most common isolated Gram-negative microorganism was Serratia marcescens (16.4%). Levofloxacin (97.4%), meropenem (97.1%), imipenem (95.6%), ciprofloxacin (95.4%) and amikacin (94.8) were the most sensitive antibiotics to Gram-negative micro-organisms. Sepsis-related mortality rate was 16% (n=23) in nosocomial sepsis caused by Gram-negative microorganisms. Conclusions: Carbapenem seems to be the best option for nosocomial sepsis caused by Gram-negative micro-organisms in our neonatal intensive care unit. Every unit must evaluate causative agents and antimicrobial susceptibilities in order to select the appropriate empirical therapy for nosocomial sepsis.