An Unbiased Way to Estimate Total Quantities: The Fractionator Technique

Kaplan S., Canan S., Altunkaynak M. E., Odaci E., Aslan H., Unal B.

NEUROQUANTOLOGY, vol.10, no.1, pp.54-65, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 1
  • Publication Date: 2012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.54-65
  • Karadeniz Technical University Affiliated: Yes


The fractionator is a straightforward and unbiased method to estimate virtually any type of total quantity using sectional profiles of tissue particles. Its basic principle and ease of use make this approach is a method of choice in many microscopical quantitative studies. In this review, we will summarize the basic principles of the fractionator approach and give some examples focused especially on some basic topics in neuroscience research.