Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

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Mentese E., Bektas H., Ulker S., BEKİRCAN O., KAHVECİ B.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.29, no.1, pp.64-68, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.3109/14756366.2012.753880
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.64-68
  • Keywords: Benzimidazole, iminoester hydrochloride, lipase inhibition, microwave, VITRO ANTIMICROBIAL ACTIVITY, SCREENING IN-VITRO, DESIGN, POTENT
  • Karadeniz Technical University Affiliated: Yes

Abstract

A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.