JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.29, no.1, pp.64-68, 2014 (SCI-Expanded)
Article / Article
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Benzimidazole, iminoester hydrochloride, lipase inhibition, microwave, VITRO ANTIMICROBIAL ACTIVITY, SCREENING IN-VITRO, DESIGN, POTENT
Karadeniz Technical University Affiliated:
A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.