Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

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Mentese E., Bektas H., Ulker S., BEKİRCAN O., KAHVECİ B.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.29, sa.1, ss.64-68, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/14756366.2012.753880
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.64-68
  • Anahtar Kelimeler: Benzimidazole, iminoester hydrochloride, lipase inhibition, microwave, VITRO ANTIMICROBIAL ACTIVITY, SCREENING IN-VITRO, DESIGN, POTENT
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the synthesis of benzimidazoles, we synthesized ester and hydrazide derivatives under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and 3b, 3c, 5a and 6a showed lipase inhibition at various concentrations.