Spectrophotometric<i> in</i><i> vitro</i> cholinergic enzyme inhibitory potentials of novel functional Schiff bases and their peripheral CoII and CuII phthalocyanines in the treatment of Alzheimer's disease

YALAZAN H., SEYHAN G., Boguslu C., BARUT B., KANTEKİN H.

POLYHEDRON, vol.277, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 277
  • Publication Date: 2025
  • Doi Number: 10.1016/j.poly.2025.117567
  • Journal Name: POLYHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica
  • Keywords: Acetylcholinesterase (AChE), Alzheimer's disease, Butyrylcholinesterase (BChE), Inhibitory, Phthalocyanine, Schiff base
  • Karadeniz Technical University Affiliated: Yes

Abstract

Cholinergic neurons and presynaptic indicators of the cholinergic system gradually disappear as a result of neurodegenerative disorders, including Alzheimer's disease (AD), one of the most prevalent causes of dementia. By inhibiting acetylcholinesterase (AChE) and thus reducing the rate of acetylcholine hydrolysis, these effects can be counteracted. Anticholinesterase medications that have reversible inhibitory effects are therefore used to treat neurodegenerative illnesses. This work involved the synthesis of Schiff base compounds (Schiffb.OH/CN) and their cobalt (Schiffb.CoPc) and copper (Schiffb.CuPc) phthalocyanine compounds, as well as spectrophotometric analysis of their in vitro cholinergic enzyme inhibitory potentials. Overall, it was found that, when compared to the other compounds examined, Schiffb.CuPc was the most potent inhibitor. Furthermore, it exhibited statistically comparable results to the positive control, galantamine (26.17 +/- 0.52 mu M). However, at the concentrations examined, it was shown that the compounds exhibited no action against BuChE. The compounds may be selective for AChE, according to this research.