Early kidney injury in immunoglobulin A vasculitis: Role of renal biomarkers

Ture E., Yazar A., Akin F., Topcu C., Aydin A., Balasar M., ...Daha Fazla

PEDIATRICS INTERNATIONAL, cilt.63, sa.10, ss.1218-1222, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/ped.14600
  • Dergi Adı: PEDIATRICS INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1218-1222
  • Anahtar Kelimeler: child, immunoglobulin A vasculitis, kidney injury molecule-1, nephropathy, neutrophil gelatinase-associated lipocalin, HENOCH-SCHONLEIN PURPURA, FOLLOW-UP, MOLECULE-1, PROTEINURIA, EXPRESSION
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background We aimed to determine whether urine kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) can be used as early noninvasive biomarkers of kidney injury in immunoglobulin A vasculitis. Methods Patients who were diagnosed with immunoglobulin A vasculitis were included in the study. Urine samples were collected for determination of urine KIM-1 and NGAL levels. The control group consisted of age-matched healthy children. Results Sixty-one patients who were diagnosed with immunoglobulin A vasculitis were included in the study; 37.7% of these patients were determined to have renal involvement. Median KIM-1 was found to be significantly higher in the patient group (69.59 pg/mL) than the control group (40.84 pg/mL) (P = 0.001). Median NGAL was determined to be statistically significantly higher in the patient group (59.87 ng/mL) compared with the control group (44.87 ng/mL) (P = 0.013). In 23.6% of the patients without renal involvement at admission renal involvement developed within the following 6 months. When median KIM-1 and NGAL at admission of these patients were compared with the control group, they were determined to be statistically significantly higher (P = 0.001, P = 0.003). Conclusions The fact that our patients with late-term nephropathy had no hematuria and / or proteinuria and that KIM-1 and NGAL levels were determined to be high indicates that these biomarkers might be potentially reliable, noninvasive and early determinants of kidney injury.