Effects of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy
INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.106, pp.87-94, 2001 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 106
- Publication Date: 2001
- Doi Number: 10.3109/00207450109149739
- Journal Name: INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.87-94
- Karadeniz Technical University Affiliated: No
Abstract
The effects of testosterone and clomiphene on epilepsy was studied in a young man with posttraumatic seizures. In the control period, digital EEG and visual evoked potentials (VEPs) were recorded under carbamazapine therapy. After testosterone (T), seizures lessened and almost disappeared; the theta, delta, alpha, and beta powers decreased; VEPs increased. After clomiphene, VEPs considerably increased in size; clinical picture slightly improved; EEG power spectrum remained unchanged. It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain.