Effects of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy


Tan M., Tan U.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.106, pp.87-94, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 106
  • Publication Date: 2001
  • Doi Number: 10.3109/00207450109149739
  • Title of Journal : INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Page Numbers: pp.87-94

Abstract

The effects of testosterone and clomiphene on epilepsy was studied in a young man with posttraumatic seizures. In the control period, digital EEG and visual evoked potentials (VEPs) were recorded under carbamazapine therapy. After testosterone (T), seizures lessened and almost disappeared; the theta, delta, alpha, and beta powers decreased; VEPs increased. After clomiphene, VEPs considerably increased in size; clinical picture slightly improved; EEG power spectrum remained unchanged. It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain.