Effects of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy

Tan M., Tan U.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.106, pp.87-94, 2001 (SCI-Expanded) identifier identifier identifier


The effects of testosterone and clomiphene on epilepsy was studied in a young man with posttraumatic seizures. In the control period, digital EEG and visual evoked potentials (VEPs) were recorded under carbamazapine therapy. After testosterone (T), seizures lessened and almost disappeared; the theta, delta, alpha, and beta powers decreased; VEPs increased. After clomiphene, VEPs considerably increased in size; clinical picture slightly improved; EEG power spectrum remained unchanged. It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain.