Antinociceptive efficacy of levetiracetam in a mice model for painful diabetic neuropathy

Ozcan M., Ayar A., Canpolat S., Kutlu S.

ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol.52, no.7, pp.926-930, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 7
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1399-6576.2007.01578.x
  • Journal Name: ACTA ANAESTHESIOLOGICA SCANDINAVICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.926-930
  • Keywords: levetiracetam, painful diabetic neuropathy, mice, ANTICONVULSANT, RETIGABINE, MECHANISM
  • Karadeniz Technical University Affiliated: No

Abstract

Background and Objective: Despite important advances in available knowledge, management of neuropathic pain remains incomplete, and results from experimental and clinical studies indicate that some anticonvulsants show promise for treating neuropathic pain. The aim of this study was to assess the antinociceptive efficacy of levetiracetam (LEV, ucb L059) in a mice model for painful diabetic neuropathy using the in vivo nociceptive behavioral 'hot-plate test.'