Antinociceptive efficacy of levetiracetam in a mice model for painful diabetic neuropathy

Ozcan M., Ayar A., Canpolat S., Kutlu S.

ACTA ANAESTHESIOLOGICA SCANDINAVICA, cilt.52, sa.7, ss.926-930, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1399-6576.2007.01578.x
  • Dergi Adı: ACTA ANAESTHESIOLOGICA SCANDINAVICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.926-930
  • Anahtar Kelimeler: levetiracetam, painful diabetic neuropathy, mice, ANTICONVULSANT, RETIGABINE, MECHANISM
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background and Objective: Despite important advances in available knowledge, management of neuropathic pain remains incomplete, and results from experimental and clinical studies indicate that some anticonvulsants show promise for treating neuropathic pain. The aim of this study was to assess the antinociceptive efficacy of levetiracetam (LEV, ucb L059) in a mice model for painful diabetic neuropathy using the in vivo nociceptive behavioral 'hot-plate test.'