Methylprednisolone Concentrations in Breast Milk and Serum of Patients with Multiple Sclerosis Treated with IV Pulse Methylprednisolone

Karahan S. Z., BOZ C., Terzi M., Aktoz G., Sen S., Ozbudun B., ...Daha Fazla

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.197, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 197
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.clineuro.2020.106118
  • Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, MEDLINE
  • Anahtar Kelimeler: Multiple sclerosis, postpartum relapse, breast milk, maternal serum, methylprednisolone, RELAPSES, PHARMACOKINETICS, PREGNANCY
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: It is commonly known that women with multiple sclerosis (MS) have an increased risk for relapses during the post-partum period. High-dose IV methylprednisolone is the first-line treatment for acute relapses. Methylprednisolone is administered to lactating women although there is insufficient data as to the levels of concentration in breast milk and serum, and the calculated steroid exposure to infants.