Methylprednisolone Concentrations in Breast Milk and Serum of Patients with Multiple Sclerosis Treated with IV Pulse Methylprednisolone

Karahan S. Z., BOZ C., Terzi M., Aktoz G., Sen S., Ozbudun B., ...More

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.197, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 197
  • Publication Date: 2020
  • Doi Number: 10.1016/j.clineuro.2020.106118
  • Journal Name: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, MEDLINE
  • Keywords: Multiple sclerosis, postpartum relapse, breast milk, maternal serum, methylprednisolone, RELAPSES, PHARMACOKINETICS, PREGNANCY
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: It is commonly known that women with multiple sclerosis (MS) have an increased risk for relapses during the post-partum period. High-dose IV methylprednisolone is the first-line treatment for acute relapses. Methylprednisolone is administered to lactating women although there is insufficient data as to the levels of concentration in breast milk and serum, and the calculated steroid exposure to infants.