Optimization of process parameters in oriented strand board (OSB) manufacturing is a vital issue for improving product quality. In this study, the Taguchi method (TM) was applied to determine the effects of production factors such as adhesive ratio, press pressure, and pressing time on the thermal conductivity of OSB. Obtained results showed that adhesive ratio is the main factor affecting thermal conductivity. Press pressure and pressing time are the second and third most important factors influencing thermal conductivity, respectively. The study also identified the optimal values of factors that minimize thermal conductivity.