Akademik Veri Yönetim Sistemi
Food and Health, cilt.9, sa.3, ss.201-211, 2023 (Hakemli Dergi)
Oxidative modifications of lipoproteins are crucial in the early stages of cardiovascular diseases (CVD) like hypercholesterolemia. The major aim is to determine the effects of hazelnut consump- tion on the resistance of low- and high-density lipoproteins to oxidation in hypercholesterolemic subjects. Fifteen hypercholesterolemic subjects (13 men, 2 women) who did not require drug tre- atment according to the National Cholesterol Education Program Adult Treatment Panel III criteria and had serum levels of TC˃200 mg/dL were included in the study. This study was designed as a dual control sandwich model intervention with a single group, isoenergetic three periods. The pe- riods were; Control Diet I (30 days), Hazelnut-Enriched Diet (30 days), and Control Diet II (30 days). The susceptibility of LDL and HDL to copper-mediated oxidation was determined spect- rophotometrically by following conjugated diene formation. The resistance of lipoproteins, mainly LDL, was increased by hazelnut consumption. It can be concluded that a hazelnut-enriched diet had protective effects against lipoprotein oxidation in hypercholesterolemic subjects. These chan- ges may play important roles in reducing the development of the atherosclerotic process.