Sildenafil citrate inhibits agonist induced contractions in isolated rat seminal vesicles

Orhan I., Onur R., Tasdemir C., Ayar A. , Kadioglu A.

JOURNAL OF UROLOGY, vol.175, no.6, pp.2350-2353, 2006 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 175 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1016/s0022-5347(06)00280-1
  • Title of Journal : JOURNAL OF UROLOGY
  • Page Numbers: pp.2350-2353


Purpose: Sildenafil is reported to regulate smooth muscle contractility through nitric oxide-cyclic guanosine monophosphate, not only in the corpus cavernosum. Its possible effects on seminal vesicle contractility might be of importance with respect to premature ejaculation. We investigated the effects of sildenafil citrate (Pfizer, New York, New York) on agonist induced isometric contractions of the rat seminal vesicle in vitro.