Sildenafil citrate inhibits agonist induced contractions in isolated rat seminal vesicles

Orhan I., Onur R., Tasdemir C., Ayar A., Kadioglu A.

JOURNAL OF UROLOGY, vol.175, no.6, pp.2350-2353, 2006 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 175 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1016/s0022-5347(06)00280-1
  • Journal Name: JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2350-2353
  • Keywords: muscle contraction, seminal uesicles, testis, sildenafil, rats, Wistar, PREMATURE EJACULATION, NITRIC-OXIDE, VAS-DEFERENS, IN-VITRO, DYSFUNCTION, EFFICACY, TENSION, VIAGRA, DRUGS
  • Karadeniz Technical University Affiliated: No


Purpose: Sildenafil is reported to regulate smooth muscle contractility through nitric oxide-cyclic guanosine monophosphate, not only in the corpus cavernosum. Its possible effects on seminal vesicle contractility might be of importance with respect to premature ejaculation. We investigated the effects of sildenafil citrate (Pfizer, New York, New York) on agonist induced isometric contractions of the rat seminal vesicle in vitro.