Sildenafil citrate inhibits agonist induced contractions in isolated rat seminal vesicles

Orhan I., Onur R., Tasdemir C., Ayar A., Kadioglu A.

JOURNAL OF UROLOGY, cilt.175, sa.6, ss.2350-2353, 2006 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 175 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/s0022-5347(06)00280-1
  • Dergi Adı: JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2350-2353
  • Anahtar Kelimeler: muscle contraction, seminal uesicles, testis, sildenafil, rats, Wistar, PREMATURE EJACULATION, NITRIC-OXIDE, VAS-DEFERENS, IN-VITRO, DYSFUNCTION, EFFICACY, TENSION, VIAGRA, DRUGS
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Purpose: Sildenafil is reported to regulate smooth muscle contractility through nitric oxide-cyclic guanosine monophosphate, not only in the corpus cavernosum. Its possible effects on seminal vesicle contractility might be of importance with respect to premature ejaculation. We investigated the effects of sildenafil citrate (Pfizer, New York, New York) on agonist induced isometric contractions of the rat seminal vesicle in vitro.