Polyneuropathy, Myopathy and Hepatitis in a Child with Nephrotic Syndrome


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BAHAT ÖZDOĞAN E. , Camlar S. A. , Irmak E., AYDIN MUNGAN S. , ÇAKIR M. , GAZİOĞLU S.

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, vol.25, no.3, pp.309-312, 2016 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.5262/tndt.2016.1003.16
  • Title of Journal : TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
  • Page Numbers: pp.309-312

Abstract

Acute sensorimotor polyneuropathy that resembles Guillain-Barre syndrome (GBS) and hepatitis is rarely accompanied with nephrotic syndrome. Its underlying immunological mechanisms are unclear. Involvement of immunological processes against common antigens in the glomerulus, peripheral nervous system and liver has been suggested. We describe a 5-year-old boy patient with acute sensorimotor polyneuropathy, myopathy and hepatitis that was accompanied with nephrotic syndrome. Renal biopsy showed membranoproliferative glomerulonephritis (MPGN). He was in remission on nephrotic syndrome and polyneuropathy at his 6-month follow-up. Approximately 40 cases have been reported in the literature and to our knowledge he is the first patient with these four conditions. In conclusion, this case report suggests that the same underlying immunological mechanisms appear in relation with each other.