The Etiology and Clinical Features of Non-CAH Gonadotropin-Independent Precocious Puberty: A Multicenter Study

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Atay Z., Yesilkaya E., Erdeve S. S., DEMİRCİOĞLU S., Akin L., EREN E., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.101, no.5, pp.1980-1988, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 101 Issue: 5
• Publication Date: 2016
• Doi Number: 10.1210/jc.2015-3500
• Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1980-1988
• Karadeniz Technical University Affiliated: Yes

Abstract

Aim: The causes of gonadotropin-independent precocious puberty are diverse, and often have overlapping clinical and biochemical features. With the exception of congenital adrenal hyperplasia (CAH), disorders that cause gonadotropin-independent precocious puberty (GIPP) are uncommon. The literature is devoid of any large-scale studies on the etiologic distribution of GIPP. The aim of this study was to determine the frequency of each etiology in a cohort of patients with GIPP (excluding those with CAH), and to evaluate the clinical and laboratory features of these patients.