Akademik Veri Yönetim Sistemi
4th International Conference on Recent Trends in Materials Science & Devices 2026 (ICRTMD-2026), Bathinda, Hindistan, 6 - 08 Nisan 2026, ss.448-449, (Özet Bildiri)
Silver and its compounds are known to act as antimicrobial biomaterials. After the discovery of silver sulfadiazine as a potent antimicrobial silver(I) complex, interest in the design and synthesis of novel antimicrobial silver(I) complexes bearing various ligands have increased. Barbiturates are the derivatives of barbituric acid and the 5-subtituted derivatives of barbituric acid were used as sedative and hypnotic drugs. The recent findings indicated that silver(I) complexes with 5,5-diethylbarbiturate (barb) show significant antimicrobial activity on different pathogens, including fungi, Gram(-) and Gram(+) bacteria. The silver(I) barb complexes containing some N-donor ligands, polypyridines, mono- and diphosphines as biomaterials were synthesized, structurally characterized, and their antimicrobial potentials were investigated on selected bacteria and fungi. In some cases, the interaction of the silver(I) complexes with biomolecules such as DNA and HSA was studied using in vitro and in silico methods.