Effects of high dose medroxyprogesterone acetate on endogenous granulocyte macrophage - colony stimulating factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy


Aydin F., Demirkazik A., Icli F., Akbulut H., Samur M.

JOURNAL OF CHEMOTHERAPY, vol.10, no.5, pp.394-398, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 5
  • Publication Date: 1998
  • Doi Number: 10.1179/joc.1998.10.5.394
  • Title of Journal : JOURNAL OF CHEMOTHERAPY
  • Page Numbers: pp.394-398

Abstract

Endogenous cytokine release and bone marrow cellularity of cancer patients receiving chemotherapy were investigated to elucidate the effect of high dose medroxyprogesterone acetate (MPA). MPA (1000 mg/day p.o.) was started after the first cycle of chemotherapy in patients with neutropenia. Administration of MPA was stopped a week after the second cycle of chemotherapy. Blood samples and bone marrow aspirations were obtained for granulocyte macrophage - colony stimulating factor (GM-CSF) assay one week after the first and second cycles of chemotherapy. GM-CSF levels and bone marrow cellularities were compared before and after MPA treatment.