Background/Purpose: Osteoporosis can appear as a result of metabolic acidosis in patients with bladder augmentation and total bladder replacement. These patients must be monitored for early diagnosis and osteoporosis to avoid related complications such as fracture. The current method for diagnosis of osteoporosis mainly involves bone densitometry. Dual x-ray absorptiometry (DXA) provides bone mineral content and bone mineral density (BMD). The purpose of this report is to determine the value of BMD measurement with DXA in the diagnosis and follow-up of osteoporosis and evaluation of response to treatment in the patients with bladder augmentation and total bladder replacement.