Determination of aluminum concentrations of parenteral nutrition solutions by HPLC

Öztürk E. , Yildirim S. , Akyol Mutlu A.

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2020
  • Doi Number: 10.1038/s41430-020-00741-0


Aluminum (Al) contamination of parenteral nutrition (PN) solutions has been known for over 30 years. In particular, vascular intake of Al leads to its accumulation in tissues. In this study, 8 all-in-one PN solutions the aluminum concentration was analyzed by high-performance liquid chromatography. The mean Al concentration of the glucose solutions of the PN solutions combinations was 16.36 +/- 8.31 mu g/L, the mean Al concentration of the amino acid solutions was 4.96 +/- 3.73 mu g/L, and the mean Al concentration of the lipid solutions was 9.09 +/- 11.23 mu g/L. The Al concentration of the PN(5)glucose and PN(2)lipid solutions were above 25 mu g/L, which is the limit set by the Food and Drug Administration (FDA). No studies in the literature have examined the Al concentrations of all-in-one PN solutions via HPLC. In two of the analyzed solutions, the Al concentration was found to be higher than the limit set by the FDA.