In this study, modeling the effect of discharge waters from various industrial establishments located along the Degirmendere basin in Trabzon was investigated. Discharges from industrial establishments directly influence the water quality of the Degirmendere River, which is also influenced by inputs resulting from sewage, industrial processes, and agricultural run-off water discharge. Wastewaters are often discharaed continuously into this river. The organic compounds found in the water are utilized by aquatic microorganisms and consequently reduce the dissolved oxygen (DO) concentration in the river. Models of DO profiles are useful in predicting possible consequences of additional river discharges or aeration strategies on the river. Input data for the model was the average of data collected between 1996 and 2004. The resulting four different scenarios were indicative of the effects of industrial discharge water, especially the dynamics of DO, BOD5, temperature, and fecal coliform in the Degirmendere River.