The effects of nitric oxide: Synthase inhibitors on acute necrotising pancreatitis in rats


Alhan E. , Küçüktülü U., Ercin C.

EUROPEAN JOURNAL OF SURGERY, vol.164, no.9, pp.697-702, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 164 Issue: 9
  • Publication Date: 1998
  • Doi Number: 10.1080/110241598750005598
  • Title of Journal : EUROPEAN JOURNAL OF SURGERY
  • Page Numbers: pp.697-702

Abstract

bstract

Objective: To investigate the effects of the constitutive nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-Name) and the inducible NO synthase inhibitor amino ethyl-isothiourea (AE-ITU) on acute necrotising pancreatitis (ANP) in rats.

Design: Laboratory study.

Setting: Medical school, Turkey.

Main outcome measures: Morbidy, mortality, effects on activities of various enzymes, and histological picture.

Results: NO inhibitors increased the mortality (from 8/15, 53%, for ANP plus saline, to 12/15, 80%, for ANP plus L-Name, and 13/15, 87%, for ANP plus AE-ITU and serum amylase activity, but had no effects on serum calcium concentrations, volume of ascites, or degree of pancreatic damage. L-Name caused hypoglycemia, and AE-ITU reduced activites of lactate dehydrogenase and liver transaminases, and concentrations of urea and creatinine.

Conclusions: Constitutive NO synthase inhibition worsens the course of ANP, and inducible NO inhibition has beneficial effects on various systems.

Objective: To investigate the effects of the constitutive nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-Name) and the inducible NO synthase inhibitor amino ethyl-isothiourea (AE-ITU) on acute necrotising pancreatitis (ANP) in rats.