Selective anastasis induction by bee venom in normal cells: a promising strategy for breast cancer therapy with minimal impact on cell viability

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Tetikoglu S., Akcan M., Uzuner U., Çelik Uzuner S.

JOURNAL OF ZHEJIANG UNIVERSITY: SCIENCE B, cilt.26, ss.1121-1131, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1631/jzus.b2400466
  • Dergi Adı: JOURNAL OF ZHEJIANG UNIVERSITY: SCIENCE B
  • Derginin Tarandığı İndeksler: Scopus, Aerospace Database, Agricultural & Environmental Science Database, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, Biotechnology Research Abstracts, Communication Abstracts, CAB Abstracts, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1121-1131
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Anastasis is a phenomenon described as a cellular escape from ethanol-induced cell death. Although the relevant mechanism has not yet been fully elucidated, anastasis is thought to play a role in drug resistance in cancer cells. To date, the regulation of anastasis in normal and cancerous cells has not been clarified. The current cancer treatment strategies are expected to selectively attack cancer cells without negatively affect‐ing normal cell proliferation. Inspired by the anti-cancer potential of bee venom, this study is the first to evalu‐ate whether bee venom has similar selectivity in pro‐ducing an anastatic effect. The results indicated that bee venom induces anastasis in normal cells (Michigan Cancer Foundation-10A (MCF10A), Adult Retinal Pig‐ment Epithelium cell line-19 (ARPE-19), and National Institutes of Health 3T3 cell line (NIH3T3)) but causes irreversible cell death in breast cancer cells