The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

URALOĞLU M., LİVAOĞLU M., AGDOĞAN Ö., ERSÖZ Ş., Karacal N.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.48, sa.3, ss.653-660, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/sag-1710-73
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.653-660
  • Anahtar Kelimeler: Low molecular weight heparin, burn, stasis zone, THERMAL-INJURY, VASCULAR-RESPONSE, RAT MODEL, MICROCIRCULATION, PROGRESSION, PREVENTION, VIABILITY, ISCHEMIA, THERAPY, CELL
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis.