The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

URALOĞLU M., LİVAOĞLU M., AGDOĞAN Ö., ERSÖZ Ş., Karacal N.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.48, no.3, pp.653-660, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.3906/sag-1710-73
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.653-660
  • Keywords: Low molecular weight heparin, burn, stasis zone, THERMAL-INJURY, VASCULAR-RESPONSE, RAT MODEL, MICROCIRCULATION, PROGRESSION, PREVENTION, VIABILITY, ISCHEMIA, THERAPY, CELL
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis.