Akademik Veri Yönetim Sistemi
JOURNAL OF COORDINATION CHEMISTRY, cilt.73, sa.7, ss.1177-1190, 2020 (SCI-Expanded)
In this study, the novel phthalonitrile derivatives 1 and 2 were synthesized. Tetra-substituted metal-free 1a (H2Pc) and metallophthalocyanines (ZnPc 1b, CoPc 1c and CuPc 1d) bearing four peripheral 4-allyl-2,6-dimethoxyphenol (methoxy-eugenol) groups and octa-substituted metal-free 2a and metallophthalocyanines (ZnPc 2b, CoPc 2c and CuPc 2d) bearing eight peripheral methoxy-eugenol group were synthesized. All new synthesized compounds are characterized by IR, C-13{H-1} NMR (for 1 and 2), UV-Vis (for 1a-2d) and mass spectroscopy. Antimicrobial activities of the synthesized phthalonitrile derivatives (1 and 2) and phthalocyanine compounds 1a-2d were determined by microdilution broth method against nine different bacteria and one yeast species. In this study, CoPc (2c) compound, which has eight peripheral 4-allyl-2,6-dimethoxyphenol, had the highest antibacterial activity (minimum inhibitory concentration [MIC] = 312 mu g/mL). In addition, 1b, 1d, 2b and 2d were found to be effective on at least three different bacterial species at different concentrations (MIC = 1250-5000 mu g/mL). Shigella flexneri were the most affected bacteria, but none of the compounds were effective against fungal isolate.