Bursitis, inflammation of small synovial fluid-filled pads, can be septic or nonseptic. Cases of bursitis are usually reported in adults, and to the best our knowledge, there is no report of bursitis in the neonatal period. In this report, we present the case of a newborn with prepatellar bursitis secondary to Staphylococcus aureus sepsis. Septic prepatellar bursitis is a rare infection in children and should be considered in the differential diagnosis of patients presenting with swelling of the knee. Early diagnosis and appropriate treatment can reduce morbidity and the need for surgery.