Evaluation of the relationship between toxicity of cyclin-dependent kinase 4/6 inhibitors and body surface area

Dişli Ş. Y., FİDAN E.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, vol.69, no.12, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 12
  • Publication Date: 2023
  • Doi Number: 10.1590/1806-9282.20230680
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Body measures, Breast cancer, Drug toxicity, Toxicity
  • Karadeniz Technical University Affiliated: No


OBJECTIVE: This study aimed to evaluate the relationship between the toxicity of cyclin-dependent kinase 4/6 inhibitors and body mass index and body surface area.METHODS: A total of 83 patients were included in the study. Patients were divided into 4 groups as 18-24.9, 25-29.9, 30-39.9, and >40 kg/m(2) according to body mass index and into two groups as below and above 1.77 according to body surface area. The relationship between body mass index and body surface area and side effects was evaluated.RESULTS: No statistically significant difference was found between body mass index groups and side effects. Grade 3 neutropenia was more common in patients on palbociclib with a body surface area <= 1.77. In our study, it was revealed that less hematological side effects can be encountered when body surface area is taken into account.