Synthesis, extraction and antibacterial studies of some new bis-1,2,4-triazole derivatives part II

GÜMRÜKÇÜOĞLU N., Ugras S., Ugras H. I., Cakir U.

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol.73, pp.359-367, 2012 (SCI-Expanded) identifier identifier


The treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole 3 with various bis-aldehydes resulted in the formation of bis-4-arylidenamino-3,5-diphenyl-4H-1,2,4-triazoles (4a-d) derivatives. NaBH4 reduction of 4-arylidenamino derivatives of 1,2,4-triazoles afforded 4-arylamino-3,5-diphenyl-4H-1,2,4-triazoles (5a-d). The synthesized all new triazole derivatives of the Schiff base and corresponding bis amino compounds 4a,d-5a,d were characterized by IR, H-1-NMR, C-13-NMR spectral data. In order to investigate the relative effects of the differences between the structures of the synthesized triazole derivatives on their extraction-abilities and-selectivities for different metal cations, constants of oveall extraction (logK (ex)) of 1:1 (M:L) complexes, the extractions (logK (ex)) for CHCl3/H2O systems have been determined with ICP-AES spectroscopy at 25 +/- A 0.1 A degrees C. Remarkable complexation properties are found towards some transition metal cations. The stability sequences of the triazole derivatives in CHCl3 for the metal cations generally found in order: Fe(III) > Cu(II) > Pb(II) > Co(II) > Zn(II) > Mn(II) > Ni(II) > Mg(II) > Ca(II). The synthesized all compounds were tested for antimicrobial activity against 11 bacteria.