A convenient synthesis of 4-amino-3,5-dialkyl-4H-1,2,4-triazoles


Ikizler A., Demirbas N., Ikizler A.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.33, sa.6, ss.1765-1769, 1996 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Konu: 6
  • Basım Tarihi: 1996
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.1765-1769

Özet

Ester tert-butoxycarbonylhydrazones 2 were reacted with some carboxylic acid hydrazides to give 4-tert-butoxycarbonylamino-3,5-dialkyl-4H-1,2,4-triazoles 3-6. Treatment of 3-5 with 6 N hydrochloric acid under mild conditions resulted in the formation of 4-amino-3,5-dialkyl-4H-1,2,4-triazole hydrochlorides 7-9 in good yields. Compound 79 was converted to the free 4-amino compound 10a upon treatment with ethanolic sodium ethoxide solution.