A convenient synthesis of 4-amino-3,5-dialkyl-4H-1,2,4-triazoles

Ikizler A., Demirbas N., Ikizler A.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.33, no.6, pp.1765-1769, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 1996
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1765-1769
  • Karadeniz Technical University Affiliated: No

Abstract

Ester tert-butoxycarbonylhydrazones 2 were reacted with some carboxylic acid hydrazides to give 4-tert-butoxycarbonylamino-3,5-dialkyl-4H-1,2,4-triazoles 3-6. Treatment of 3-5 with 6 N hydrochloric acid under mild conditions resulted in the formation of 4-amino-3,5-dialkyl-4H-1,2,4-triazole hydrochlorides 7-9 in good yields. Compound 79 was converted to the free 4-amino compound 10a upon treatment with ethanolic sodium ethoxide solution.