The Effects of high fat diets with and without N-Acetylcysteine supplementation on the lipin-1 levels of serum and various tissues in rats
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.39, sa.1, ss.19-24, 2014 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.5505/tjb.2014.78941
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.19-24
- Anahtar Kelimeler: N-acetylcysteine, high fat diet, low fat diet, lipin-1, obesity, rat, OXIDATIVE STRESS, EXPRESSION, INFLAMMATION, PHOSPHATASE, METABOLISM, INCREASES, CYSTEINE, WHITE
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Objective: Obesity is a public health problem, but the struggle against obesity continues to increase every day. Lipin-1 is an adipokine that modulates lipid metabolism and glucose homeostasis. The aims of the current study were to compare the levels of lipin-1 in serum and tissues (liver, lung, heart, pancreas and kidney) in rat fed with low fat diet (LFD), high fat diet (HFD) and N-acetylcysteine (NAC) supplemented HFD, and to determine the relationships of the lipin-1 levels in serum and tissues with the levels of serum glucose and lipid parameters.