The Value of Neopterin and Procalcitonin in Patients with Sepsis

Fisgin N. T., Aliyazicioglu Y., Tanyel E., Coban A. Y., Ulger F., Zivalioglu M., ...Daha Fazla

SOUTHERN MEDICAL JOURNAL, cilt.103, sa.3, ss.216-219, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/smj.0b013e3181cf11a1
  • Dergi Adı: SOUTHERN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.216-219
  • Anahtar Kelimeler: procalcitonin, neopterin, sepsis, MULTIPLE ORGAN DYSFUNCTION, SEPTIC SHOCK, INFLAMMATORY RESPONSE, INTENSIVE-CARE, PLASMA-LEVELS, SERUM, COMPLICATIONS, PREDICTION, INFECTION, CYTOKINES
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: Neopterin (NT) is a compound of low molecule-based pteridine. It is secreted by macrophages as a response to the stimulation of cytokines such as interferon-gamma, interferon-1 beta, tumor necrosis factor alpha or bacteria compounds such as lipopolysaccharides. Procalcitonin (PCT) levels may increase in the course of bacterial, parasitic, and fungal infections. Therefore, it can be used for the differential diagnosis of the infection, especially in cases of serious inflammation. In this study, the role of NT, and PCT in sepsis as a prognostic factor, and the relationship between the two parameters are examined.