Use of polypharmacotherapy in pregnancy: a prospective outcome in a case

YARIS F. , Yaris E. , Kadioglu M., ULKU C., Kesim M., Kalyoncu N. İ.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.28, no.3, pp.603-605, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 28 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.pnpbp.2004.01.010
  • Page Numbers: pp.603-605
  • Keywords: atypical antipsychotic, biperiden, mirtazapine, oxerutine, pregnancy, quetiapine, risperidone, thrombophlebitis, WOMEN


Purpose: Little is known about the risks associated with prenatal exposure to atypical antipsychotics. Our objective is to present a case of exposure to risperidone and quetiapine in pregnancy, and additionally to some other drugs. Case: Our case (36-year old) has suffered schizophrenia (DSM-IV) for 5 years and used these drugs (risperidone, quetiapine, mirtazapine, thioridazine, diazepam, hydroxyzine, clomipramine, fluvoxamine, alprazolam, carbamazepine, biperiden, haloperidol, ampicillin + sulbactam, enoxaparin, oxerutine) in her third pregnancy. Because of her psychotic condition, Mrs. N.B. was not aware of her pregnancy until 22nd week and the pregnancy could not be terminated. She had a female infant (3000 g, 50 cm) with APGAR scores of 8-9 at the first and fifth minutes at 37th week with an uncomplicated vaginal delivery. The baby was normal. Conclusion: This case may contribute to the existing knowledge regarding use of atypical antipsychotics in pregnancy. (C) 2004 Elsevier Inc. All rights reserved.