Long-term Treatments with Low- and High-dose Olanzapine Change Hepatocyte Numbers in Rats. A Stereological and Histopathological Study

Odaci E., Bilen H., HACIMÜFTÜOĞLU A., KELEŞ O. N., Can I., BİLİCİ M.

ARCHIVES OF MEDICAL RESEARCH, vol.40, no.3, pp.139-145, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1016/j.arcmed.2009.02.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.139-145
  • Karadeniz Technical University Affiliated: Yes


Background and Aims. Olanzapine, an atypical antipsychotic agent, has been commonly used to treat schizophrenia and bipolar mania because it demonstrates better efficacy for negative schizophrenic symptoms and has minimal extrapyramidal side effects compared to typical antipsychotic drugs. Recent reports of serious hepatotoxicity induced by olanzapine have been published. In this study we aimed to evaluate the effects of long-term administration of low and high doses of olanzapine on rat livers.