Long-term Treatments with Low- and High-dose Olanzapine Change Hepatocyte Numbers in Rats. A Stereological and Histopathological Study


Odaci E. , Bilen H., HACIMÜFTÜOĞLU A., KELEŞ O. N. , Can I., BİLİCİ M.

ARCHIVES OF MEDICAL RESEARCH, cilt.40, sa.3, ss.139-145, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Konu: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.arcmed.2009.02.006
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Sayfa Sayıları: ss.139-145

Özet

Background and Aims. Olanzapine, an atypical antipsychotic agent, has been commonly used to treat schizophrenia and bipolar mania because it demonstrates better efficacy for negative schizophrenic symptoms and has minimal extrapyramidal side effects compared to typical antipsychotic drugs. Recent reports of serious hepatotoxicity induced by olanzapine have been published. In this study we aimed to evaluate the effects of long-term administration of low and high doses of olanzapine on rat livers.