JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.951, 2021 (SCI-Expanded)
In this study, novel 1-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine substituted phthalocyanine Zn(II), Pb(II) and Co(II) complexes (ZnPc, PbPc, CoPc) were synthesized and proposed structures were confirmed by FT-IR, NMR, UV-vis and MS instrumental techniques. The inhibition potentials of these newly synthesized Pc compounds on, alpha-amylase and tyrosinase enzymes were investigated. PbPc molecule was found to be most active against alpha-amylase (IC50 value 7.3 +/- 0.3 mu M) and tyrosinase (IC50 value 6.7 +/- 0.6 mu M). Kinetic studies showed that the inhibition mechanism of PbPc molecule on tyrosinase and alpha-amylase activity was mixed-type. (C) 2021 Elsevier B.V. All rights reserved.