A convenient synthesis of some 3-alkylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Kahveci B. , Bekircan O., Serdar M., Ikizler A.

REVUE ROUMAINE DE CHIMIE, vol.48, no.8, pp.615-618, 2003 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 8
  • Publication Date: 2003
  • Title of Journal : REVUE ROUMAINE DE CHIMIE
  • Page Numbers: pp.615-618


A series of 3-arylidenamino-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-ones N were obtained from the reaction of 3-amino-4-phenyl-45-dihydro-1H-1,2,4-triazol-5-one IVa with certain aldehydes. Compounds V were hydrogenated with NaBH, in diglyme to afford 3-alkylamino-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-ones. VI. So, a general and convenient method was improved for the synthesis of type VI compounds. Eleven new and potential biologically active compounds were synthesized and characterized by elemental analyses, C-13-NMR, H-1-NMR, UV and IR spectra.