Paget's Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels
TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS, cilt.26, sa.2, ss.136-138, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 2
- Basım Tarihi: 2020
- Doi Numarası: 10.4274/tod.galenos.2019.15046
- Dergi Adı: TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.136-138
- Anahtar Kelimeler: Paget's disease, alkaline phosphatase, bone scintigraphy, ZOLEDRONIC ACID, BONE TURNOVER
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
Paget's disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of bone turnover in Paget's disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range. The treatment of symptomatic forms relies on bisphosphonates that are efficient in reducing the bone turnover. Here, I present the case of an 80-year-old man suffering from chronic low back pain, and diagnosed as Paget's disease, with normal serum alkaline phosphatase and bone-specific alkaline phosphatase levels.