Paget's Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels
TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS, vol.26, no.2, pp.136-138, 2020 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 26 Issue: 2
- Publication Date: 2020
- Doi Number: 10.4274/tod.galenos.2019.15046
- Journal Name: TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.136-138
- Keywords: Paget's disease, alkaline phosphatase, bone scintigraphy, ZOLEDRONIC ACID, BONE TURNOVER
- Open Archive Collection: AVESIS Open Access Collection
- Karadeniz Technical University Affiliated: No
Abstract
Paget's disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of bone turnover in Paget's disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range. The treatment of symptomatic forms relies on bisphosphonates that are efficient in reducing the bone turnover. Here, I present the case of an 80-year-old man suffering from chronic low back pain, and diagnosed as Paget's disease, with normal serum alkaline phosphatase and bone-specific alkaline phosphatase levels.