Synthesis, <i>in vitro</i> antioxidant and antimicrobial activities of some novel 3-sub stitued-4-(3-methoxy-4-isobutyryloxybenzylideneamino)-4,5-dihydro-1<i>H</i>-1,2,4-triazol-5-one derivatives
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, sa.2, ss.271-282, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2020
- Dergi Adı: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Index Chemicus (IC)
- Sayfa Sayıları: ss.271-282
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
In this study, 3-alkyl(ary1)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones have been reacted with 3-methoxy-4-isobutyryloxybenzaldehyde 2 to afford the corresponding nine new 3-alkyl(ary1)-4-(3-methoxy-4-isobutyryloxybenzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3. Then, the acetylation reactions of compounds 3 have been investigated and 4 type compounds have been obtained. The compounds 3 have also been treated with morpholine/1-methylpiperazine in the presence of formaldehyde according to the Mannich reaction to synthesize 1(morpholine-4-yl-methyl)-3-allcyl(ary1)-4-(3-methoxy-4-i sohutyryloxy-benzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5ones 5, and 1-(1-methylpiperazin-4-yl-methyl)-3-alkyl(ary1)-4-(3-methoxy-4-isobutyryloxybenzylideneamino)-4,5-dihydro1H-1,2,4-triazol-5-ones 6, respectively. The structures of twenty four new compounds have been characterized by IR, H-1 and C-13 NMR and MS spectroscopic methods. In addition, the newly synthesized compounds have been screened for their antimicrobial activities. Furthermore, these twenty four new compounds have been analyzed for their in vitro potential antioxidant activities by three different methods.