Research Information System
Türk Dermatoloji Dergisi, vol.20, no.1, pp.25-32, 2026 (ESCI, Scopus, TRDizin)
Aim: Allergic contact dermatitis (ACD) may accompany atopic dermatitis (AD) more frequently than previously recognized. This study aimed to identify concomitant contact sensitization and common allergens in patients with refractory AD. Materials and Methods: In this prospective single-center study (September 2022–February 2024), 62 AD patients with treatment-resistant or atypically distributed lesions suggestive of contact dermatitis underwent patch testing using the European baseline series. Patch test reactions were evaluated on days 2 and 4 according to International Contact Dermatitis Research Group criteria; reactions graded as + or higher were considered positive. Results were compared with those of 306 non-AD patients who underwent patch testing for suspected ACD during the same period. Results: The positivity rate for at least one allergen in AD patients was 62.9%, which was significantly higher than that observed in non-AD patients (40.2%). Nickel sulfate was the most frequently identified allergen. Conclusion: These findings suggest that patients with AD may have increased susceptibility to contact sensitization, and patch testing in recalcitrant cases may help identify potential triggering allergens.