Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Feldman P., Parveen N., SEZEN F. S.

BRAIN RESEARCH, vol.709, no.2, pp.331-336, 1996 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 709 Issue: 2
  • Publication Date: 1996
  • Doi Number: 10.1016/0006-8993(95)01434-9
  • Journal Name: BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.331-336
  • Karadeniz Technical University Affiliated: No


Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for mu receptors, and the delta antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of delta-, and possibly mu-, opioid receptors in the dorsal vagal complex.