Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Feldman P., Parveen N., SEZEN F. S.

BRAIN RESEARCH, cilt.709, ss.331-336, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier identifier

  • Cilt numarası: 709 Konu: 2
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1016/0006-8993(95)01434-9
  • Sayfa Sayıları: ss.331-336


Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for mu receptors, and the delta antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of delta-, and possibly mu-, opioid receptors in the dorsal vagal complex.