Brain metabolite values in children with breath-holding spells

Calik M., Sen Dokumaci D., Sarikaya S., Demir M., Isik I., Kazanasmaz H., ...More

NEUROPSYCHIATRIC DISEASE AND TREATMENT, vol.13, pp.1655-1660, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2017
  • Doi Number: 10.2147/ndt.s135842
  • Journal Name: NEUROPSYCHIATRIC DISEASE AND TREATMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1655-1660
  • Karadeniz Technical University Affiliated: No

Abstract

Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells.