Synthesis, characterization, and alpha-glucosidase, cholinesterases, and tyrosinase inhibitory effects of axial substituted silicon and peripheral tetra-substituted copper (II), manganese (III) phthalocyanines


Ozturmen B. A., BARUT B., BIYIKLIOĞLU Z.

APPLIED ORGANOMETALLIC CHEMISTRY, vol.36, no.8, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.1002/aoc.6781
  • Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
  • Keywords: cholinesterases, phthalocyanine, synthesis, tyrosinase, alpha-glucosidase, AGGREGATION, DERIVATIVES
  • Karadeniz Technical University Affiliated: Yes

Abstract

In this paper, we have synthesized axially di-(3,3-diphenylpropoxy) substituted silicon (DFP-Si) and peripherally tetra-(3,3-diphenylpropoxy) substituted copper (II), manganese (III) phthalocyanines (DFP-Cu, DFP-Mn). Then, the a-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory effects of DFP-Si, DFP-Cu, and DFP-Mn were examined using spectrophotometric methods. DFP-Mn had the highest inhibitor effect on cholinesterases, tyrosinase, and a-glucosidase in a concentration-dependent manner. DFP-Mn inhibited alpha-glucosidase with IC50 value of 17.80 mu M. Also, DFP-Mn also showed higher alpha-glucosidase inhibitory actions that acarbose used as a positive control. The inhibition percentages in the presence of DFP-Mn were 30.64 +/- 2.24%, 51.96 +/- 1.56%, and 72.96 +/- 4.95%, respectively at 20, 40, and 100 mu M on AChE. In the presence of DFP-Mn at 100 mu M, the inhibition percentages were calculated as 52.18 +/- 2.22% against tyrosinase. These results showed that the compound has potential to treat Diabetes mellitus but further studies are needed to confirm the antidiabetic effect of the compound.