Non-aggregated and water soluble axially disubstituted silicon phthalocyanines: Synthesis and inhibitory effect on acetylcholinesterase enzyme

BIYIKLIOĞLU Z., BaS H., Sahin H.

APPLIED ORGANOMETALLIC CHEMISTRY, vol.36, no.6, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.1002/aoc.6668
  • Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
  • Keywords: acetylcholinesterase, Alzheimer's disease, phthalocyanine, silicon, water solubility, DERIVATIVES, BUTYRYLCHOLINESTERASE, DESIGN
  • Karadeniz Technical University Affiliated: Yes

Abstract

In this study, axially pyridine groups substituted silicon (IV) phthalocyanines (3PY-7-Si and 3PY-8-Si) and their water soluble derivatives 3PY-7a-SiQ and 3PY-8a-SiQ were synthesized and acetylcholinesterase inhibition properties were examined. Axially pyridine groups substituted silicon (IV) phthalocyanines (3PY-7-Si and 3PY-8-Si) and their water soluble derivatives 3PY-7a-SiQ and 3PY-8a-SiQ showed the various degrees of acetylcholinesterase inhibition activity. Their IC50 values causing 50% inhibition of the enzyme were ranged between 0.598 +/- 0.068 and 0.886 +/- 0.016 mM which 3PY-7a-SiQ was the best. These results demonstrated that the compounds might be effective agents against Alzheimer's disease.