APPLIED ORGANOMETALLIC CHEMISTRY, vol.36, no.6, 2022 (SCI-Expanded)
In this study, axially pyridine groups substituted silicon (IV) phthalocyanines (3PY-7-Si and 3PY-8-Si) and their water soluble derivatives 3PY-7a-SiQ and 3PY-8a-SiQ were synthesized and acetylcholinesterase inhibition properties were examined. Axially pyridine groups substituted silicon (IV) phthalocyanines (3PY-7-Si and 3PY-8-Si) and their water soluble derivatives 3PY-7a-SiQ and 3PY-8a-SiQ showed the various degrees of acetylcholinesterase inhibition activity. Their IC50 values causing 50% inhibition of the enzyme were ranged between 0.598 +/- 0.068 and 0.886 +/- 0.016 mM which 3PY-7a-SiQ was the best. These results demonstrated that the compounds might be effective agents against Alzheimer's disease.