Conventional and microwave irradiated synthesis, biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids

MERMER A., Demirci S., OZDEMIR S. B., DEMİRBAŞ A., ULKER S., AYAZ F. A., ...More

CHINESE CHEMICAL LETTERS, vol.28, no.5, pp.995-1005, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1016/j.cclet.2016.12.012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.995-1005
  • Keywords: Fluoroquinolone, 1,2,4-Triazole, Microwave, Mannich reaction, Biological activity, Molecular docking, ASSISTED SYNTHESIS, ACID-DERIVATIVES, ANTIBACTERIAL ACTIVITY, ANTIFUNGAL ACTIVITY, MANNICH-BASES, DESIGN, ANTIBIOTICS, INHIBITORS, DENSITY, AGENTS
  • Karadeniz Technical University Affiliated: Yes


Azole derivatives (3, 6) obtained starting from 1-(2-methoxyphenyl)piperazine were converted to the corresponding Mannich bases containing beta-lactame or flouroquinolone core via a one pot three component reaction. The synthesis of conazole analogues was carried out starting from triazoles by three steps. Reactions were carried out under conventional and microwave mediated conditions. All the newly synthesized compounds were screened for their antimicrobial: enzyme inhibition and antioxidant activity, and most of them displayed good-moderate activity. Binding affinities and non-covalent interactions between enzyme-ligand complexes were predicted with molecular docking method at molecular level. Docking results complemented well the experimental results on a-glucosidase and urease inhibitory effects of the compounds. Higher binding affinities and much more interaction networks were observed for active compounds in contrary to inactive ones. It was predicted with the docking studies that triazole and anisole moieties in the structure of the synthesized compounds contributed to the stabilization of corresponding enzymes through non-covalent interactions. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.