Electropolymerized Poly(Bromocresol Purple) as a Signal-Amplifying Interface for the Highly Sensitive Voltammetric Quantification of Antifungal Drug Terbinafine
ELECTROCATALYSIS, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Kısa Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s12678-026-01050-z
- Dergi Adı: ELECTROCATALYSIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Chemical Abstracts Core, Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
The electrochemical analysis of terbinafine, an antifungal drug available for oral and topical use, was investigated using poly(bromocresol purple) modified glassy carbon electrode. The surface of the bare electrodes was coated by one-step electropolymerization of bromocresol purple monomer via cyclic voltammetry in a pH 6.0 phosphate buffer solution, resulting in at least a two-fold increase in terbinafine peak current compared to the bare glassy carbon electrode. Electrochemical analysis revealed that terbinafine undergoes irreversible and diffusion-controlled oxidation. Quantitative analysis of terbinafine using differential pulse voltammetry yielded a detection limit of 19.0 nM and a linearity range of 0.08-20.0 & micro;M. Results with relative standard deviations below 2.0% demonstrated that the method possesses good precision and ruggedness and that the prepared electrode exhibited good reproducibility. Accuracy studies using both the tablet dosage form and synthetic urine showed recoveries of 99.66% and 100.14%, respectively, revealing that the proposed method provided good selectivity, sensitivity, and accuracy without interference from inactive excipients.