Synthesis, Extraction, and Anti-Bacterial Studies of Some New Bis-1,2,4-triazole Derivatives Part I

GÜMRÜKÇÜOĞLU N., Ugras S., Ugras H. I., Cakir U.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.123, no.4, pp.2011-2019, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1002/app.34700
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2011-2019
  • Keywords: 4-Amino-4H-1,2,4-triazole, bis-1,2,4-triazoles, bisSchiff bases, extraction ability-selectivity, anti-bacterial activity, ION-PAIR EXTRACTION, SOLVENT-EXTRACTION, FUNDAMENTAL EQUILIBRIA, AROMATASE INHIBITORS, ORGANIC-SOLVENTS, METAL PICRATES, CROWN ETHERS, K+, ELUCIDATION, SELECTIVITY
  • Karadeniz Technical University Affiliated: Yes


A series of new bis triazole Schiff base derivatives (4) were prepared in good yields by treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole (3) with bisaldehydes (1). Schiff bases (4) were reduced with NaBH4 to afford the corresponding bisaminotriazoles (5). All the new compounds were characterized by IR, H-1 NMR and C-13 NMR spectral data. Their overall extraction (log K-ex) constants for 1 : 1 (M : L) complexes and CHCl3/H2O systems were determined at 25 +/- 0.1 degrees C to investigate the relationship between structure and selectivity toward various metal cations. The extraction equilibrium constants were estimated using CHCl3/H2O membrane transfer with inductively coupled plasma-atomic emission spectroscopy spectroscopy. The stability sequence of the triazole derivatives in CHCl3 for the metal cations was exhibited a characteristic preference order of extractability to metal ions [Fe(III) > Cu(II) > Pb(II) > Co(II) > Ni(II) > Mn(II) > Zn(II) > Mg(II) > Ca(II)]. The compounds were tested for anti-microbial activity applying agar diffusion technique for 11 bacteria. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 2011-2019, 2012