Desmoplastic Small Round Cell Tumor Presenting as an Ocular Mass: Unusual Localization and Remarkable Surgical Approach

YALDIZ ÇOBANOĞLU H. B., Hanna E. Y., Bell D., Esmaeli B.

CURRENT ONCOLOGY REPORTS, cilt.19, sa.12, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 19 Sayı: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s11912-017-0638-x
  • Dergi Adı: CURRENT ONCOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Desmoplastic, Chemotherapy, Surgery, Proton therapy, SURVIVAL, RADIOTHERAPY, FUSION
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Desmoplastic small round cell tumor (DSRCT) is a rare tumor that was first described by Gerald and Rosai in 1989 as a mesenchymal entity. This tumor has a unique translocation t (11:22) (p:13, q:12) resulting in EWS/WT1 gene fusion that is diagnostic for DSCRT. The overall prognosis for desmoplastic small round cell tumor remains extremely poor, with reported rates of death as high as 90%. Although the majority of patients undergo chemotherapy following surgery, the prognosis has been shown to be independent of whether the surgical process preceded or followed chemotherapy. In this review, we provide insights for the management of DSCRT that requires aggressive multimodality therapy.