Cardioprotective effect of cold-blood cardioplegia enriched with N-acetylcysteine during coronary artery bypass grafting


KORAMAZ İ., Pulathan Z. , USTA S., KARAHAN S. C. , ALVER A. , YARIS E. , ...Daha Fazla

ANNALS OF THORACIC SURGERY, cilt.81, ss.613-618, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 81 Konu: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.athoracsur.2005.08.013
  • Dergi Adı: ANNALS OF THORACIC SURGERY
  • Sayfa Sayıları: ss.613-618

Özet

Background. Cold-blood cardioplegia is a well-known method in coronary artery bypass graft surgery, and several authors have used various agents in the enrichment of cold-blood cardioplegia to decrease ischemia-reperfusion injury seen during surgery. N-acetylcysteine, which can increase glutathione levels, is one of the agents added to cardioplegic solutions to decrease myocardial injury. This study was planned to assess the efficiency of N-acetylcysteine-enriched cold-blood cardioplegia on early reperfusion injury in patients with ischemic heart disease undergoing coronary artery bypass grafting, using measurements of cardiac troponin I and malondialdehyde release.