Cardioprotective effect of cold-blood cardioplegia enriched with N-acetylcysteine during coronary artery bypass grafting


KORAMAZ İ., Pulathan Z. , USTA S., KARAHAN S. C. , ALVER A. , YARIS E. , ...More

ANNALS OF THORACIC SURGERY, vol.81, no.2, pp.613-618, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.athoracsur.2005.08.013
  • Title of Journal : ANNALS OF THORACIC SURGERY
  • Page Numbers: pp.613-618

Abstract

Background. Cold-blood cardioplegia is a well-known method in coronary artery bypass graft surgery, and several authors have used various agents in the enrichment of cold-blood cardioplegia to decrease ischemia-reperfusion injury seen during surgery. N-acetylcysteine, which can increase glutathione levels, is one of the agents added to cardioplegic solutions to decrease myocardial injury. This study was planned to assess the efficiency of N-acetylcysteine-enriched cold-blood cardioplegia on early reperfusion injury in patients with ischemic heart disease undergoing coronary artery bypass grafting, using measurements of cardiac troponin I and malondialdehyde release.