Cardioprotective effect of cold-blood cardioplegia enriched with N-acetylcysteine during coronary artery bypass grafting.
The Annals of thoracic surgery, vol.81, no.2, pp.613-8, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 81 Issue: 2
- Publication Date: 2006
- Doi Number: 10.1016/j.athoracsur.2005.08.013
- Journal Name: The Annals of thoracic surgery
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.613-8
- Karadeniz Technical University Affiliated: Yes
Abstract
Background. Cold-blood cardioplegia is a well-known method in coronary artery bypass graft surgery, and several authors have used various agents in the enrichment of cold-blood cardioplegia to decrease ischemia-reperfusion injury seen during surgery. N-acetylcysteine, which can increase glutathione levels, is one of the agents added to cardioplegic solutions to decrease myocardial injury. This study was planned to assess the efficiency of N-acetylcysteine-enriched cold-blood cardioplegia on early reperfusion injury in patients with ischemic heart disease undergoing coronary artery bypass grafting, using measurements of cardiac troponin I and malondialdehyde release.