Cardioprotective effect of cold-blood cardioplegia enriched with N-acetylcysteine during coronary artery bypass grafting.

KORAMAZ İ., Pulathan Z., USTA S., KARAHAN S. C., ALVER A., YARIS E., ...Daha Fazla

The Annals of thoracic surgery, cilt.81, sa.2, ss.613-8, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 81 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.athoracsur.2005.08.013
  • Dergi Adı: The Annals of thoracic surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.613-8
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background. Cold-blood cardioplegia is a well-known method in coronary artery bypass graft surgery, and several authors have used various agents in the enrichment of cold-blood cardioplegia to decrease ischemia-reperfusion injury seen during surgery. N-acetylcysteine, which can increase glutathione levels, is one of the agents added to cardioplegic solutions to decrease myocardial injury. This study was planned to assess the efficiency of N-acetylcysteine-enriched cold-blood cardioplegia on early reperfusion injury in patients with ischemic heart disease undergoing coronary artery bypass grafting, using measurements of cardiac troponin I and malondialdehyde release.