Cyclic triterpenoid saponins from Campanula lactiflora

Yayli N., usta a., usta a., ÜÇÜNCÜ O., Gulec C., KÜÇÜKİSLAMOĞLU M.

Turkish Journal of Chemistry, vol.30, no.1, pp.21-28, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2006
  • Journal Name: Turkish Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.21-28
  • Keywords: Campanula lactiflora, lactifloroside A and B, campanuloic acid, 15-deoxycampanuloic acid, cyclic bisdemoside
  • Karadeniz Technical University Affiliated: Yes

Abstract

Two cyclic natural compounds, 3β-O-[α-L-rhamnopyranosyl- (1→2)-β-D-glucopyranosyl]-13α,14α-epoxy-8α,12β, 15-trihydroxy-(17E,21E)-17,21-campanuldien-6′ (30)-olide, called lactifloroside A, 1, and 3β-O-[β-D-glucopyranosyl-(1→2)-β-D- glucopyranosyl]-13α,14α-epoxy-8α,12β-dihydroxy-(17E,21E) -17,21-campanuldien-6′ (30)-olide, called lactifloroside B, 2, were isolated for the first time from Campanula lactiflora and their structures deduced by high field 1D and 2D 400 MHz NMR, FT-IR, HPLC, GC-MS, (+/-) LC-MS/MS and (+) FAB-MS spectra. The aglycones of the 2 saponins were named 13α,14α-epoxy-3β,8α,12β,15-tetrahydroxy-(17E,21E) -17,21-campanuldien-30-oic acid and 13α,14α-epoxy-3β,8α, 12β-trihydroxy-(17E,21E)-17,21-campanuldien-30-oic acid, and designated as campanuloic acid and 15-deoxycampanuloic acid, respectively. © TÜBİTAK.