HETEROGENEITY OF 5-HT RESPONSIVENESS IN DIFFERENT SEGMENTS OF RABBIT ARTERIES
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, cilt.100, sa.2, ss.159-164, 1992 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 100 Sayı: 2
- Basım Tarihi: 1992
- Doi Numarası: 10.3109/13813459209035280
- Dergi Adı: ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA)
- Sayfa Sayıları: ss.159-164
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
The variation in sensitivity to serotonin (5-HT) as assessed by pD2 was investigated in isolated 25 arterial segments of different vascular regions obtained from rabbits. The responses of the vascular rings which were opened by a transverse cut to form rectangular strips were recorded isometrically. pD2 values for 5-HT of thoracic and abdominal aortic segments were significantly greater than those of visceral arterial branches. Maximal contractions produced by 5-HT in visceral segments were higher than those of thoracic and abdominal aortic segments. There was a positive correlation between the pD2 values for 5-HT and the radii and the thickness of the tunica media layer (r = 0.62 and r = 0.54, respectively, P < 0.05). The results indicate that the activity of 5-HT varies regionally in different segments of the rabbit arteries and the sensitivity to 5-HT of the segments decreases as the radii of the vessels diminish.