Chlorine-Thymol Substituted Silicon (IV) Phthalocyanines: Synthesis, Characterization, and In Vitro Acetylcholinesterase (AChE)/Butyrylcholinesterase (BChE) Inhibitory Effect

Kamiloğlu A. A., Arslan T., Tekin A., Kantekin H., Acar İ.

APPLIED ORGANOMETALLIC CHEMISTRY, vol.39, no.1, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2025
  • Doi Number: 10.1002/aoc.7757
  • Journal Name: APPLIED ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
  • Keywords: acetylcholinesterase, Alzheimer's disease, butyrylcholinesterase, silicon phthalocyanine, thymol
  • Karadeniz Technical University Affiliated: Yes

Abstract

In this study, novel chlorine-thymol derivatives (1,3-bis(4-chloro-2-isopropyl-5 methylphenoxy)propan-2-ol (Thy-OHI) and 2-[2-(4-chloro-2-isopropyl-5-methylphenoxy)ethoxy]ethanol (Thy-OHII)) and axially di-4-chloro-2-isopropyl-5-methylphenoxy (Thy-SiPc), 1,3-bis(4-chloro-2-isopropyl-5-methylphenoxy)propanoxy (Thy-OHI-SiPc), and 2-[2-(4-chloro-2-isopropyl-5-methylphenoxy)ethoxy]ethanoxy (Thy-OHII-SiPc) substituted silicon phthalocyanine compounds were obtained, and their structures were elucidated by the combination of various methods such as NMR, IR, UV-Vis, and MS. The inhibitory effects of these compounds (Thy-OHI, Thy-(OHI)-I-II, Thy-SiPc, Thy-OHI-SiPc and Thy-OHII-SiPc), synthesized for the first time, on cholinesterase enzymes (AChE and BChE) were investigated in the laboratory environment. In the studies, notably Thy-OHI-Si and thymol derivative ligand Thy-OHII displayed significant inhibition against AChE and BChE.