Akademik Veri Yönetim Sistemi
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, cilt.69, 2025 (ESCI, Scopus)
Species of the Crataegus L. genus are well-regarded on account of their diverse and abundant secondary metabolite composition, and they are recognized as a valuable source of bioactive and aromatic compounds. This research conducts a comprehensive assessment of both the chemical constituents and biological effects of Crataegus persimilis 'Prunifolia' fruit extracts grown in Turkey. LC-HRMS and ATR-FTIR analyses were utilized for compound characterization, and antioxidant as well as enzyme inhibitory activities were thoroughly evaluated through detailed bioassays. Quantitative analysis of total phenolic and flavonoid contents revealed that the ethyl acetate extract contained the highest levels, with 99.0 +/- 3.3 mg GAE/g for phenolics and 19.0 +/- 0.3 mg QE/g for flavonoids. Among the 14 identified compounds, fumaric acid, (-)-epicatechin, and chlorogenic acid were identified as the principal components and showed strong correlations with antioxidant capacity. The ethyl acetate extract also demonstrated notable enzyme inhibition, particularly against a-amylase (IC5o: 20.0 +/- 0.6 mu g/mL), a-glucosidase (IC50: 225.0 +/- 5.3 mu g/riaL), and tyrosinase (IC50: 6.0 +/- 0.0 mu g/mL). Furthermore, multivariate analysis confirmed the relationship between total bioactive content and observed biological effects. The study highlights the potential of Crataegus persimilis 'Prunifolia' fruit as a natural source of therapeutically relevant phenolic compounds for use in health-related applications.