Results of treatment regime of FLAG-Ida-Cyclosporine in acute leukemia patients refractory to FLAG salvage regime FLAG kurtarma tedavisine refrakter akut lösemi vakalarinda FLAG-İdarubisin-Siklosporin tedavisi sonuçlari

SÖNMEZ M., YILMAZ M., ERKUT M., Akdoǧan E., Durmuş A., Omay S. B., ...Daha Fazla

UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.15, sa.3, ss.144-148, 2005 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2005
  • Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.144-148
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Although the salvage regimens can induce complete remission in refractory acute leukemia patients, it is generally short and rarely cure is achieved. The plan for refractory patients with respect to salvage regimens is problematic. The emergence of multidrug resistance cause the inefficiency of chemotherapy protocols. Cyclosporine is one of the agents to overcome the drug resistance. In this study, we planned to test the efficiency of hybrid regime FLAG-Ida-Cyclosporine in the refractory cases to FLAG. 9 patients who were primary refractory or relapsed to FLAG salvage regime comprising 5 AML, 3 ALL and 1 T-lymphoblastic lymphoma were enrolled. In 3 out of 5 AML patients, complete remission was observed, however none of ALL and T-lymphoblastic lymphoma patients entered remission. These results suggested that FLAG-Ida-Cyclosporine therapy can be an alternative in the AML patients primary refractory or early relapsed to FLAG salvage regimen, in contrast to the inefficiency in ALL cases.